Peptides are the new way to support younger-looking skin
Your skin deserves more than surface care.
POISELLE targets multiple signs of skin aging
How peptides work
Peptides are short chains of amino acids, the building blocks of skin proteins. In skincare they act as messengers that help skin look firmer, smoother and more resilient.
Shop peptide serumsFine lines
10% Argireline™ and Matrixyl 3000 target the look of fine and dynamic expression lines.
See the serumFirmness
Copper peptides (GHK-Cu), including 2% liposomal GHK-Cu, support skin that looks firmer and more elastic.
See the serum
Texture
5% PDRN from salmon DNA with exosomes helps skin look renewed, smooth and refined.
See the serumEvery formula, built to work together
Peptides do the long-term work. Hydrators, barrier lipids and botanicals make every drop feel good from day one.
Lightweight gel texture
A silky, fast-absorbing serum that layers under moisturizer and makeup without pilling.
Shop serums
Barrier support
Ceramides and panthenol help skin hold on to moisture and stay comfortable.
Meet ceramidesDeep hydration
High- and low-weight hyaluronic acid hydrate the surface and help skin look plump.
See hydration serumsAntioxidant care
Green tea and vitamin E help defend skin from everyday environmental stress.
Explore ingredientsSmoother-looking surface
PDRN, exosomes and peptides help refine the look of uneven texture over time.
Shop for textureOne routine, every key peptide
| POISELLE Peptides | Retinol | Vitamin C | Basic moisturizer | |
|---|---|---|---|---|
| Gentle on sensitive skin | ✓ | ⊘ | Partial | ✓ |
| Supports a firmer look | ✓ | ✓ | Partial | ⊘ |
| Hydrates while it works | ✓ | ⊘ | ⊘ | ✓ |
| Daily AM & PM use | ✓ | ⊘ | ✓ | ✓ |
General comparison of ingredient types, for illustration.
Our standards
Korean-inspired, cruelty-free formulas made for daily use on all skin types.
Peptide serums
Each built around a signature peptide system.
PDRN
50,000 ppm in our PDRN Salmon DNA Serum.
Argireline™
For the look of dynamic expression lines.
Key ingredients
Peptides, hydrators and botanicals that work together.
Clinical results
Visibly smoother-looking skin
81% witnessed smoother skin*
Consumer results
witness smoother skin*
say skin feels stronger & less irritated**
see smoother skin with less deep forehead wrinkles***
★ average rating on Amazon, Copper Peptide Serum
*, **, *** Consumer perception results for POISELLE. † Advanced Multi Peptide Serum. ¹ Clinically measured results for POISELLE 10% Argireline Serum. Individual results vary.
Frequently asked questions
Have more questions? Visit our Help Center, write to official@poiselle.com or call +1 307-443-5727.
What is a peptide serum?
A peptide serum is a lightweight skincare formula containing peptides, which are chains of amino acids commonly used in skincare to support the appearance of smoother, firmer, and healthier-looking skin. POISELLE peptide serums combine carefully selected peptides with ingredients such as Hyaluronic Acid, Ceramides, Niacinamide, and botanical extracts to provide hydration and targeted skincare benefits.
How do I use a POISELLE serum?
Apply your POISELLE serum to clean, dry or slightly damp skin, depending on the individual product directions. Apply a few drops to the face and neck and gently press or massage until absorbed. Follow with moisturizer. During the daytime, finish with sunscreen. Because each POISELLE serum has a different formulation, always follow the specific directions provided on its individual product page.
When in my routine should I apply a POISELLE serum?
Generally, apply your serum after cleansing and toning and before moisturizer. If you use multiple skincare products, apply lighter, water-based products before heavier creams or oils. POISELLE serums can be incorporated into morning and evening routines, depending on the specific product. Always check the individual product directions for recommended use.
Can I use a POISELLE serum with my other skincare products?
Yes. POISELLE serums are designed to fit easily into a layered skincare routine. They can generally be followed with moisturizer and, during the daytime, sunscreen. If you are using multiple active skincare products, introduce them gradually and pay attention to how your skin responds. For product-specific layering recommendations, refer to the directions on the individual POISELLE product page.
Are POISELLE serums suitable for all skin types?
Many POISELLE serums are formulated to be suitable for a wide range of skin types, including normal, dry, oily, combination, and sensitive skin. However, each formula is different. Please check the individual product page for its specific recommended skin types and ingredients so you can select the serum that best fits your skincare needs.
Should I patch test before using a POISELLE serum?
Yes. If you have sensitive or reactive skin, patch testing is a good precaution before introducing a new skincare product. Apply a small amount to a discreet area of skin and monitor the area before applying the product more broadly. If irritation or discomfort occurs, discontinue use. Avoid applying products to broken or irritated skin.
How long does shipping take?
Shipping times depend on the destination, shipping method selected, and order processing time. After your order has been processed and shipped, you will receive available tracking information so you can follow your delivery. For the most accurate delivery information, please refer to the shipping information provided during checkout or contact POISELLE at official@poiselle.com.
What is your returns policy?
We want you to feel confident when shopping with POISELLE. Orders are fulfilled through Amazon, so returns follow Amazon’s return policy for your order. You can see your return window in Your Orders on Amazon. If you have a question about a specific order or return, please contact us at official@poiselle.com.
How do I contact POISELLE?
We are happy to assist with questions about our products, orders, ingredients, skincare routines, and general customer support. Email: official@poiselle.com. Phone: +1 307-443-5727. Address: POISELLE, 30 N Gould St R, Sheridan, WY 82801, United States. You can also use the contact form in our Help Center.
Which POISELLE serum is right for my skin?
POISELLE offers different serum formulas designed around different skincare goals. Some focus on peptides and fine-line care, while others emphasize hydration, skin barrier support, PDRN, Copper Peptides, or Matrixyl® technology. Explore the individual serum product pages to review each formula, key ingredients, benefits, recommended skin types, and directions before choosing the serum that best fits your skincare routine.
Can I use more than one POISELLE serum?
Some POISELLE serums can be layered together as part of a customized skincare routine. However, because each serum has its own formulation and active ingredients, it is best to follow the directions provided on each individual product page. If you are introducing multiple serums, consider adding them gradually and avoid overcomplicating your routine.
Can I use POISELLE serums in the morning and at night?
Many POISELLE serums are designed for morning and evening use, but recommended frequency can vary by formula. Always check the specific product directions. If a serum contains ingredients that require more gradual introduction, follow the frequency recommended on its individual product page. For daytime routines, finish with sunscreen.
Can I use a POISELLE serum under makeup?
Yes. Many POISELLE serums have lightweight, fast-absorbing textures that can be layered under moisturizer, sunscreen, and makeup. Allow the serum to absorb before applying the next step of your routine. This can help create a smoother-feeling base for makeup.
Do POISELLE serums contain Hyaluronic Acid?
Several POISELLE formulas feature Hyaluronic Acid or Sodium Hyaluronate as part of their hydration-focused formulations. Hyaluronic Acid is commonly used in skincare to help attract and retain moisture, leaving skin feeling hydrated, soft, and supple. Check each individual product page for its complete ingredient list.
What are peptides and why are they used in POISELLE serums?
Peptides are chains of amino acids commonly used in skincare formulations designed to support the appearance of smoother, firmer, and healthier-looking skin. POISELLE uses different peptide ingredients and peptide complexes across its formulas, including Matrixyl®, Argireline®, SNAP-8, Copper Peptides, and other peptides. Each formula is designed with a specific combination of ingredients and skincare benefits.
What is Matrixyl® 3000?
Matrixyl® 3000 is a peptide complex used in skincare formulations focused on the appearance of fine lines, wrinkles, firmness, and overall skin texture. POISELLE incorporates Matrixyl® 3000 into selected formulas alongside other hydrating and skin-conditioning ingredients. Refer to each product page for the specific formula and ingredient information.
What is Argireline™?
Argireline™ is a peptide ingredient commonly used in skincare products designed to improve the appearance of expression lines and wrinkles. POISELLE's Argireline-focused serum combines Argireline™ with other skin-conditioning and hydrating ingredients to support smoother-looking skin.
What is PDRN and why is it used in skincare?
PDRN, or Polydeoxyribonucleotide, is a DNA-derived ingredient used in cosmetic skincare formulations. POISELLE incorporates PDRN into selected formulas alongside ingredients such as peptides, Hyaluronic Acid, and other skin-conditioning ingredients. For the exact PDRN concentration and complete formulation, please refer to the individual product page.
What are Copper Peptides?
Copper Peptides are peptide ingredients used in cosmetic skincare formulations designed to support the appearance of healthy, smooth, and firm-looking skin. POISELLE incorporates GHK-Cu Copper Peptides into selected formulas alongside ingredients such as PDRN, Hyaluronic Acid, and additional peptides. Please refer to the individual product page for the exact formulation and ingredient details.
How should I store my POISELLE serum?
Keep your serum tightly closed and store it in a cool, dry place away from direct sunlight and excessive heat. Avoid leaving skincare products in areas with significant temperature fluctuations, such as a hot car or direct sunlight. Always follow any storage instructions provided on the product packaging.
How many drops of serum should I use?
The recommended amount can vary depending on the POISELLE formula. Many of our serums require only a few drops to cover the face and neck. Always follow the application directions provided on the individual product page rather than applying more product than recommended.
Can POISELLE serums be used on the neck?
Many POISELLE serums can be applied to the face and neck, and some product directions specifically recommend application to these areas. Always check the individual product's directions before applying it to the neck or décolleté.
Can men use POISELLE serums?
Yes. POISELLE skincare is designed around skin needs rather than gender. Our formulas can be incorporated into skincare routines for anyone looking to support hydration, smoother-looking skin, firmness, elasticity, and overall skin appearance. Choose a serum based on your individual skin type and skincare goals.
Are POISELLE serums fragrance free?
Fragrance specifications can vary between POISELLE formulas. Some POISELLE serums are specifically formulated to be fragrance free, while individual ingredient lists may contain naturally derived aromatic ingredients or essential oils. Please check the individual product page and complete ingredient list for the most accurate information before purchasing.
How long does it take to see results?
Skincare results can vary depending on the individual, the product formula, skin type, and consistency of use. Some POISELLE products include specific product-testing or usage statements regarding visible improvements over a defined period. Where applicable, these details are provided directly on the individual product page. Consistent use according to the product directions is important.
Can I use POISELLE serum if I have sensitive skin?
Many POISELLE formulas are designed for a range of skin types, including sensitive skin. However, sensitivity can vary from person to person, and individual formulas contain different ingredients. Always review the complete ingredient list before use. If you have sensitive or reactive skin, patch testing a new product is a good precaution.
What should I do if a product causes irritation?
If you experience persistent irritation, burning, redness, or discomfort after using a skincare product, discontinue use. Allow your skin to recover and seek appropriate professional advice if the reaction is severe or does not improve. Before introducing another product, review its ingredients and consider patch testing.
Can I use POISELLE serums with retinol or other active ingredients?
This depends on the specific POISELLE serum and the other products in your routine. Because different formulas contain different active and skin-conditioning ingredients, check the individual product directions before combining products. If you are using several active skincare ingredients, introduce products gradually and avoid unnecessarily complicated routines.
Where can I find the complete ingredient list?
The complete ingredient list is provided on each individual POISELLE product page. Open the serum you are interested in and look for the “Full Ingredients” section to review the complete formula before purchasing.
How can I choose between different POISELLE peptide serums?
Start by identifying your primary skincare goal. Hydration: look for formulas featuring Hyaluronic Acid and other moisturizing ingredients. Fine-line care: consider peptide-focused formulas. Firmness and elasticity: explore formulas featuring Matrixyl®, Copper Peptides, or other peptide complexes. Barrier support: look for formulas featuring Ceramides and other skin-conditioning ingredients. PDRN-focused skincare: explore the POISELLE PDRN serum. You can also take our skin routine quiz for a personalized match.
How can I get help with my order or product?
For questions about POISELLE products, orders, ingredients, or general customer support, contact us directly and we will be happy to help. Email official@poiselle.com, call +1 307-443-5727, or send a message through our Help Center.
Are POISELLE products cruelty-free?
Yes. POISELLE serums are cruelty-free.
Can I use POISELLE if I am pregnant or nursing?
Please consult your healthcare provider before starting any new skincare product while pregnant or nursing.
Where can I buy POISELLE?
You can shop on this website or in our Amazon store. When you check out on this site, your order is completed securely on Amazon.
What payment methods do you accept?
Payment is handled at checkout on Amazon, so you can use any payment method saved in your Amazon account.
How do I change or cancel my order?
Orders are managed in Amazon. Go to Your Orders on Amazon to cancel an order before it ships. Need help? Contact us.
Do you have promo codes?
We don’t have any promo codes running right now. Sign up to our newsletter at the bottom of the page to hear about new launches.
How do I track my order?
Open Your Orders on Amazon and choose “Track package”. You can also use the Track order button at the top of the Help Center.
When will I receive my order?
You’ll see the delivery date at checkout on Amazon. Prime members get Prime delivery speeds where available.
My order arrived damaged. What should I do?
We’re sorry! Request a replacement or refund from Your Orders on Amazon, or contact us with your order number and a photo and we’ll make it right.
How do I return a product?
Go to Your Orders on Amazon, choose the POISELLE item and select “Return or replace items”. If you need help, contact us.
When will I get my refund?
Refunds are issued by Amazon to your original payment method once the return is processed.