Helps reduce fine lines & wrinkles
$39.00 1 fl oz / 30 mL
PDRN Serum with Salmon DNA: PDRN 5% + Matrixyl 3000 + Exosomes
A Korean-inspired serum with 5% PDRN (Sodium DNA), 10% Matrixyl 3000, niacinamide, panthenol and an exosome complex. Lightweight hydration for a smoother, firmer, more radiant-looking complexion.
- 5% PDRN (50,000 ppm) from salmon DNA
- 10% Matrixyl 3000 (100,000 ppm)
- Exosome complex, Niacinamide & Panthenol
- Lightweight, fragrance-free daily hydration
Free US shippingCruelty-free
Benefits
A Korean-inspired serum with 5% PDRN (Sodium DNA), 10% Matrixyl 3000, niacinamide, panthenol and an exosome complex. Lightweight hydration for a smoother, firmer, more radiant-looking complexion.
Key ingredients
PDRN (Sodium DNA) 5%A DNA-derived ingredient from salmon known for its skin-conditioning properties.RenewsConditions
Matrixyl® 3000 10%A concentrated peptide complex for a firmer, smoother-looking complexion.SmoothsFirms
Botanical ExosomesPart of the advanced PDRN and peptide delivery system.DeliversSupports
Niacinamide + PanthenolSupport hydration, comfort and a healthy-looking complexion.HydratesSoothes
Full ingredients
Water, Propanediol, Dipropylene Glycol, Butylene Glycol, Methylpropanediol, Diethoxyethyl Succinate, Glycerin, Niacinamide, 1,2-Hexanediol, Trehalose, Cetearyl Alcohol, Hydrogenated Vegetable Oil, Melia Azadirachta Leaf Extract, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Snail Secretion Filtrate, Caprylyl Methicone, Diglycerin, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Caprylic/Capric Triglyceride, Vinyl Dimethicone, Dicaprylyl Carbonate, Hydrogenated Polydecene, Pentylene Glycol, Triethylhexanoin, Cetearyl Olivate, Polymethylsilsesquioxane, Sorbitan Olivate, Panthenol, Glyceryl Stearate, Sodium Polyacrylate, Tromethamine, Ethylhexylglycerin, Cetearyl Glucoside, Ammonium Acryloyldimethyltaurate/VP Copolymer, Adenosine, Synthetic Beeswax, Dipotassium Glycyrrhizate, Allantoin, Dilauryl Thiodipropionate, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Sodium Phytate, Hydrogenated Lecithin, Ceramide NP, Beta-Glucan, Tocopherol, Salmon Testis Exosomes, Sodium DNA, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Oligopeptide-1, Acetyl Tetrapeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Carbomer, Stearyl Alcohol, Xanthan Gum.
How to use
Step 1. After cleansing and toning, dispense 1–2 pumps onto fingertips.
Step 2. Apply evenly over face and neck, focusing on fine lines. Press gently.
Step 3. Wait about 30 seconds, then follow with moisturizer.
When: Start 2–3 nights a week, then nightly
Skin type: Normal, dry, oily, combination and sensitive.
Complete your routine
Copper Peptide Serum
$39.00
GHK-Cu + PDRN Serum
$39.00
★★★★★From Amazon reviews“Impressive Copper Peptide Serum”Rafael·“My best buy”Hassam Usmani·“Solid peptide-packed serum that lightweight and layers easily”Juan Garcia·“Clearer skin after 10 days, niacinamide, copper peptides and more, not irritating to skin”Sarah·“POISELLE Copper Peptides Serum for Face”dusksi·“Impressive Combination of Peptides in One Serum”Worldgroup SysOp·“Great serum packed with a lot of skin benefiting ingredients!”Amazon Customer·“So far so good”Ashley·“Hydrating Serum That Fits Easily Into My Routine”Trying Stuff Since 2022·“Copper Peptide Serum”Amazon Customer·“Effective peptide serum with great texture and ingredients”T-Rock·“Great serum, even for sensitive skin”Abee Ward·“Packed serum”LCB·“This serum has been fantastic for keeping my skin hydrated and looking smoother!”Lilly Sky·“Good”ZuLaNi·“lightweight texture, skin doesn't feel greasy after use”Sarah Stewart·“Hydrating Peptide Serum That Makes Skin Feel Smoother”Cheesasaurus Rex·“Moisturizing”Level Up·“Nice and moisturizing”K·“Good for aging skin”C.A.H.·“Feels soothing and nourishing”SonomaGal·“Has a slight effect, so far.”Lance C.·“Impressive Copper Peptide Serum”Rafael·“My best buy”Hassam Usmani·“Solid peptide-packed serum that lightweight and layers easily”Juan Garcia·“Clearer skin after 10 days, niacinamide, copper peptides and more, not irritating to skin”Sarah·“POISELLE Copper Peptides Serum for Face”dusksi·“Impressive Combination of Peptides in One Serum”Worldgroup SysOp·“Great serum packed with a lot of skin benefiting ingredients!”Amazon Customer·“So far so good”Ashley·“Hydrating Serum That Fits Easily Into My Routine”Trying Stuff Since 2022·“Copper Peptide Serum”Amazon Customer·“Effective peptide serum with great texture and ingredients”T-Rock·“Great serum, even for sensitive skin”Abee Ward·“Packed serum”LCB·“This serum has been fantastic for keeping my skin hydrated and looking smoother!”Lilly Sky·“Good”ZuLaNi·“lightweight texture, skin doesn't feel greasy after use”Sarah Stewart·“Hydrating Peptide Serum That Makes Skin Feel Smoother”Cheesasaurus Rex·“Moisturizing”Level Up·“Nice and moisturizing”K·“Good for aging skin”C.A.H.·“Feels soothing and nourishing”SonomaGal·“Has a slight effect, so far.”Lance C.·
Why peptides?
| POISELLE Peptides | Retinol | Vitamin C | Basic moisturizer | |
|---|---|---|---|---|
| Gentle on sensitive skin | ✓ | ⊘ | Partial | ✓ |
| Supports a firmer look | ✓ | ✓ | Partial | ⊘ |
| Hydrates while it works | ✓ | ⊘ | ⊘ | ✓ |
| Daily AM & PM use | ✓ | ⊘ | ✓ | ✓ |
General comparison of ingredient types, for illustration.
PDRN
A DNA-derived ingredient from salmon known for its skin-conditioning properties.
Discover our scienceComplementary actives
PDRN (Sodium DNA) 5%
A DNA-derived ingredient from salmon known for its skin-conditioning properties.
RenewsConditionsMatrixyl® 3000 10%
A concentrated peptide complex for a firmer, smoother-looking complexion.
SmoothsFirmsBotanical Exosomes
Part of the advanced PDRN and peptide delivery system.
DeliversSupportsNiacinamide + Panthenol
Support hydration, comfort and a healthy-looking complexion.
HydratesSoothesCruelty-free
Fragrance-free
Korean-inspired
Peptide powered
The POISELLE Routine
Copper Peptide Serum$39.00 1 fl oz / 30 mL
10% Argireline Serum$39.00 30 mL
Matrixyl 3000 Serum$39.00 1 fl oz / 30 mL
PDRN Salmon DNA Serum$39.00 1 fl oz / 30 mL
Step
Firm & smooth
Expression lines
Hydrate
Night renewal
Use
AM & PM
AM & PM
AM & PM
PM, 2–3 nights a week to start
How to apply
A few drops on clean, dry skin. Massage onto face and neck.
Focus on forehead and around the eyes.
Massage onto face, neck and décolleté.
1–2 pumps after toning. Press into face and neck.
Customer reviews
No reviews yet for this serum
Tried PDRN Salmon DNA Serum? Your review helps others choose.
Review on AmazonSee what customers say about our bestselling Copper Peptide Serum.
★★★★★
Rafael
Verified purchase
September 21, 2026
Impressive Copper Peptide Serum
I am impressed with this copper peptide serum. It works exactly as advertised and gives my skin a smoother and more refreshed texture. The formula absorbs quickly and does not leave any greasy residue. Considering the affordable price, I was not expecting such a high-quality product, but it performs as well as some much more expensive serums I have tried.
★★★★★
Hassam Usmani
Verified purchase
September 7, 2026
My best buy
My skin feels firmer and looks so much smoother after 2 weeks. No irritation and absorbs really well
Frequently asked questions
Have more questions? Visit our Help Center, write to official@poiselle.com or call +1 307-443-5727.
What is a peptide serum?
A peptide serum is a lightweight skincare formula containing peptides, which are chains of amino acids commonly used in skincare to support the appearance of smoother, firmer, and healthier-looking skin. POISELLE peptide serums combine carefully selected peptides with ingredients such as Hyaluronic Acid, Ceramides, Niacinamide, and botanical extracts to provide hydration and targeted skincare benefits.
How do I use a POISELLE serum?
Apply your POISELLE serum to clean, dry or slightly damp skin, depending on the individual product directions. Apply a few drops to the face and neck and gently press or massage until absorbed. Follow with moisturizer. During the daytime, finish with sunscreen. Because each POISELLE serum has a different formulation, always follow the specific directions provided on its individual product page.
When in my routine should I apply a POISELLE serum?
Generally, apply your serum after cleansing and toning and before moisturizer. If you use multiple skincare products, apply lighter, water-based products before heavier creams or oils. POISELLE serums can be incorporated into morning and evening routines, depending on the specific product. Always check the individual product directions for recommended use.
Can I use a POISELLE serum with my other skincare products?
Yes. POISELLE serums are designed to fit easily into a layered skincare routine. They can generally be followed with moisturizer and, during the daytime, sunscreen. If you are using multiple active skincare products, introduce them gradually and pay attention to how your skin responds. For product-specific layering recommendations, refer to the directions on the individual POISELLE product page.
Are POISELLE serums suitable for all skin types?
Many POISELLE serums are formulated to be suitable for a wide range of skin types, including normal, dry, oily, combination, and sensitive skin. However, each formula is different. Please check the individual product page for its specific recommended skin types and ingredients so you can select the serum that best fits your skincare needs.
Should I patch test before using a POISELLE serum?
Yes. If you have sensitive or reactive skin, patch testing is a good precaution before introducing a new skincare product. Apply a small amount to a discreet area of skin and monitor the area before applying the product more broadly. If irritation or discomfort occurs, discontinue use. Avoid applying products to broken or irritated skin.
How long does shipping take?
Shipping times depend on the destination, shipping method selected, and order processing time. After your order has been processed and shipped, you will receive available tracking information so you can follow your delivery. For the most accurate delivery information, please refer to the shipping information provided during checkout or contact POISELLE at official@poiselle.com.
What is your returns policy?
We want you to feel confident when shopping with POISELLE. Orders are fulfilled through Amazon, so returns follow Amazon’s return policy for your order. You can see your return window in Your Orders on Amazon. If you have a question about a specific order or return, please contact us at official@poiselle.com.
How do I contact POISELLE?
We are happy to assist with questions about our products, orders, ingredients, skincare routines, and general customer support. Email: official@poiselle.com. Phone: +1 307-443-5727. Address: POISELLE, 30 N Gould St R, Sheridan, WY 82801, United States. You can also use the contact form in our Help Center.
Which POISELLE serum is right for my skin?
POISELLE offers different serum formulas designed around different skincare goals. Some focus on peptides and fine-line care, while others emphasize hydration, skin barrier support, PDRN, Copper Peptides, or Matrixyl® technology. Explore the individual serum product pages to review each formula, key ingredients, benefits, recommended skin types, and directions before choosing the serum that best fits your skincare routine.
Can I use more than one POISELLE serum?
Some POISELLE serums can be layered together as part of a customized skincare routine. However, because each serum has its own formulation and active ingredients, it is best to follow the directions provided on each individual product page. If you are introducing multiple serums, consider adding them gradually and avoid overcomplicating your routine.
Can I use POISELLE serums in the morning and at night?
Many POISELLE serums are designed for morning and evening use, but recommended frequency can vary by formula. Always check the specific product directions. If a serum contains ingredients that require more gradual introduction, follow the frequency recommended on its individual product page. For daytime routines, finish with sunscreen.
Can I use a POISELLE serum under makeup?
Yes. Many POISELLE serums have lightweight, fast-absorbing textures that can be layered under moisturizer, sunscreen, and makeup. Allow the serum to absorb before applying the next step of your routine. This can help create a smoother-feeling base for makeup.
Do POISELLE serums contain Hyaluronic Acid?
Several POISELLE formulas feature Hyaluronic Acid or Sodium Hyaluronate as part of their hydration-focused formulations. Hyaluronic Acid is commonly used in skincare to help attract and retain moisture, leaving skin feeling hydrated, soft, and supple. Check each individual product page for its complete ingredient list.
What are peptides and why are they used in POISELLE serums?
Peptides are chains of amino acids commonly used in skincare formulations designed to support the appearance of smoother, firmer, and healthier-looking skin. POISELLE uses different peptide ingredients and peptide complexes across its formulas, including Matrixyl®, Argireline®, SNAP-8, Copper Peptides, and other peptides. Each formula is designed with a specific combination of ingredients and skincare benefits.
What is Matrixyl® 3000?
Matrixyl® 3000 is a peptide complex used in skincare formulations focused on the appearance of fine lines, wrinkles, firmness, and overall skin texture. POISELLE incorporates Matrixyl® 3000 into selected formulas alongside other hydrating and skin-conditioning ingredients. Refer to each product page for the specific formula and ingredient information.
What is Argireline™?
Argireline™ is a peptide ingredient commonly used in skincare products designed to improve the appearance of expression lines and wrinkles. POISELLE's Argireline-focused serum combines Argireline™ with other skin-conditioning and hydrating ingredients to support smoother-looking skin.
What is PDRN and why is it used in skincare?
PDRN, or Polydeoxyribonucleotide, is a DNA-derived ingredient used in cosmetic skincare formulations. POISELLE incorporates PDRN into selected formulas alongside ingredients such as peptides, Hyaluronic Acid, and other skin-conditioning ingredients. For the exact PDRN concentration and complete formulation, please refer to the individual product page.
What are Copper Peptides?
Copper Peptides are peptide ingredients used in cosmetic skincare formulations designed to support the appearance of healthy, smooth, and firm-looking skin. POISELLE incorporates GHK-Cu Copper Peptides into selected formulas alongside ingredients such as PDRN, Hyaluronic Acid, and additional peptides. Please refer to the individual product page for the exact formulation and ingredient details.
How should I store my POISELLE serum?
Keep your serum tightly closed and store it in a cool, dry place away from direct sunlight and excessive heat. Avoid leaving skincare products in areas with significant temperature fluctuations, such as a hot car or direct sunlight. Always follow any storage instructions provided on the product packaging.
How many drops of serum should I use?
The recommended amount can vary depending on the POISELLE formula. Many of our serums require only a few drops to cover the face and neck. Always follow the application directions provided on the individual product page rather than applying more product than recommended.
Can POISELLE serums be used on the neck?
Many POISELLE serums can be applied to the face and neck, and some product directions specifically recommend application to these areas. Always check the individual product's directions before applying it to the neck or décolleté.
Can men use POISELLE serums?
Yes. POISELLE skincare is designed around skin needs rather than gender. Our formulas can be incorporated into skincare routines for anyone looking to support hydration, smoother-looking skin, firmness, elasticity, and overall skin appearance. Choose a serum based on your individual skin type and skincare goals.
Are POISELLE serums fragrance free?
Fragrance specifications can vary between POISELLE formulas. Some POISELLE serums are specifically formulated to be fragrance free, while individual ingredient lists may contain naturally derived aromatic ingredients or essential oils. Please check the individual product page and complete ingredient list for the most accurate information before purchasing.
How long does it take to see results?
Skincare results can vary depending on the individual, the product formula, skin type, and consistency of use. Some POISELLE products include specific product-testing or usage statements regarding visible improvements over a defined period. Where applicable, these details are provided directly on the individual product page. Consistent use according to the product directions is important.
Can I use POISELLE serum if I have sensitive skin?
Many POISELLE formulas are designed for a range of skin types, including sensitive skin. However, sensitivity can vary from person to person, and individual formulas contain different ingredients. Always review the complete ingredient list before use. If you have sensitive or reactive skin, patch testing a new product is a good precaution.
What should I do if a product causes irritation?
If you experience persistent irritation, burning, redness, or discomfort after using a skincare product, discontinue use. Allow your skin to recover and seek appropriate professional advice if the reaction is severe or does not improve. Before introducing another product, review its ingredients and consider patch testing.
Can I use POISELLE serums with retinol or other active ingredients?
This depends on the specific POISELLE serum and the other products in your routine. Because different formulas contain different active and skin-conditioning ingredients, check the individual product directions before combining products. If you are using several active skincare ingredients, introduce products gradually and avoid unnecessarily complicated routines.
Where can I find the complete ingredient list?
The complete ingredient list is provided on each individual POISELLE product page. Open the serum you are interested in and look for the “Full Ingredients” section to review the complete formula before purchasing.
How can I choose between different POISELLE peptide serums?
Start by identifying your primary skincare goal. Hydration: look for formulas featuring Hyaluronic Acid and other moisturizing ingredients. Fine-line care: consider peptide-focused formulas. Firmness and elasticity: explore formulas featuring Matrixyl®, Copper Peptides, or other peptide complexes. Barrier support: look for formulas featuring Ceramides and other skin-conditioning ingredients. PDRN-focused skincare: explore the POISELLE PDRN serum. You can also take our skin routine quiz for a personalized match.
How can I get help with my order or product?
For questions about POISELLE products, orders, ingredients, or general customer support, contact us directly and we will be happy to help. Email official@poiselle.com, call +1 307-443-5727, or send a message through our Help Center.
Are POISELLE products cruelty-free?
Yes. POISELLE serums are cruelty-free.
Can I use POISELLE if I am pregnant or nursing?
Please consult your healthcare provider before starting any new skincare product while pregnant or nursing.
Where can I buy POISELLE?
You can shop on this website or in our Amazon store. When you check out on this site, your order is completed securely on Amazon.
What payment methods do you accept?
Payment is handled at checkout on Amazon, so you can use any payment method saved in your Amazon account.
How do I change or cancel my order?
Orders are managed in Amazon. Go to Your Orders on Amazon to cancel an order before it ships. Need help? Contact us.
Do you have promo codes?
We don’t have any promo codes running right now. Sign up to our newsletter at the bottom of the page to hear about new launches.
How do I track my order?
Open Your Orders on Amazon and choose “Track package”. You can also use the Track order button at the top of the Help Center.
When will I receive my order?
You’ll see the delivery date at checkout on Amazon. Prime members get Prime delivery speeds where available.
My order arrived damaged. What should I do?
We’re sorry! Request a replacement or refund from Your Orders on Amazon, or contact us with your order number and a photo and we’ll make it right.
How do I return a product?
Go to Your Orders on Amazon, choose the POISELLE item and select “Return or replace items”. If you need help, contact us.
When will I get my refund?
Refunds are issued by Amazon to your original payment method once the return is processed.
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